Carl June, MD
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Carl June, MD
Director of Translational Research
Abramson Cancer Center
University of Pennsylvania

Oncologist, researcher, and professor Carl June is renowned pioneer in the fight against cancer. His revolutionary leukemia therapy, which was recently approved by the FDA, uses genetically engineered versions of a patient’s own T cells, and is the first personalized cell therapy for cancer to be sanctioned in America. Developed by Carl and his colleagues, this method has the potential to help patients with many other types of cancers.

Dr. Carl June is director of translational research at the Abramson Cancer Center at the University of Pennsylvania, and is an investigator of the Abramson Family Cancer Research Institute.

Dr. June’s research interests have focused on lymphocyte biology, with a major translational focus on ex vivo T cell engineering for cancer and HIV cell based therapies. His current research involves applying principles of the cellular immune system to develop novel therapies for cancer and chronic infection. His laboratory has been dedicated to develop new forms of T cell based therapies for nearly two decades. His studies discovered several principles of lymphocyte costimulation. Using these basic findings, the laboratory developed a cell culture system that was tested for the first-in-human evaluation of chimeric antigen receptors (CAR) using T cells modified with gamma retroviruses and for immune regeneration in AIDs patients. His team conducted the first clinical evaluations of lentiviruses and zinc finger nucleases as tools to modify T cells, initially in HIV and then in cancer patients with advanced leukemia.

A graduate of the Naval Academy in Annapolis and Baylor College of Medicine, he has published more than 350 manuscripts, and is the recipient of numerous prizes and honors, including election to the Institute of Medicine in 2012 and the American Academy of Arts and Sciences in 2014, as well as being named one of Time Magazine's 100 Most Influential People in 2018.

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