John J. Orloff, MD
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John J. Orloff, MD
Executive Vice President, Head of Research & Development

John Orloff, MD, is Executive Vice President, Head of Research & Development of Alexion. Dr. Orloff is focused on strengthening Alexion’s clinical pipeline and research programs, enhancing research and development productivity, overseeing regulatory and medical affairs, and supporting business development. Dr. Orloff has 20 years of experience in the biopharmaceutical industry and deep expertise spanning various stages of clinical and non-clinical development, including developing medicines for rare diseases.

Prior to joining Alexion, Dr. Orloff served as Executive Vice President, Head of Research & Development at Novelion, where he currently sits on the Board of Directors. He previously served with Baxalta as Global Head of R&D and Chief Scientific Officer, where he advanced the company’s pipeline and oversaw regulatory approval of 10 unique products and two devices. He also held executive R&D roles with Baxter International, Merck Serono, Novartis and Merck Research Laboratories. Prior to joining the biopharmaceutical industry in 1997, Dr. Orloff was with the Yale School of Medicine for seven years.

Dr. Orloff graduated magna cum laude from Dartmouth College, received his medical degree from the University of Vermont, and completed internal medicine training at the University of Pittsburgh, serving as Chief Medical Resident.

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